Zolpidem 10 mg Online

Zolpidem 10 mg Online, marketed as Ambien among others, serves as a medication mainly for addressing short-term sleeping problems. Guidelines suggest employing it only subsequent to attempting cognitive behavioral therapy for insomnia and implementing behavioral changes like sleep hygiene. It reduces the time it takes to fall asleep by approximately fifteen minutes and, at higher doses, extends the duration of sleep. It is taken by mouth and is available in conventional tablets, sublingual tablets, or oral spray.

Common side effects include daytime sleepiness, headache, nausea, and diarrhea. More severe side effects include memory problems and hallucinations. While flumazenil, a GABA_A–receptor antagonist, can reverse zolpidem’s effects, usually supportive care is all that is recommend in overdose.

Zolpidem is a nonbenzodiazepine or Z-drug which acts as a sedative and hypnotic. Zolpidem is a GABA_A receptor agonist of the imidazopyridine class. It works by increasing GABA effects in the central nervous system by binding to GABA_A receptors at the same location as benzodiazepines. It generally has a half-life of two to three hours. This, however, is increase in those with liver problems.

The United States approved Zolpidem for medical use in 1992. It entered the market as a generic medication in 2007. The Controlled Substances Act of 1970 (CSA) classifies Zolpidem as a Schedule IV controlled substance. Healthcare providers fill over ten million prescriptions for Zolpidem annually in the United States, establishing it as one of the most frequently utilized treatments for sleep issues. By 2021, it ranked as the 63rd most prescribed medication in the country, with over 10 million prescriptions.

Medical uses

Contraindications

People with obstructive sleep apnea, myasthenia gravis, severe liver disease, respiratory depression, children, or people with psychotic illnesses should not take Zolpidem. Additionally, it should not be taken by individuals who are or have been addicted to other substances

Use of zolpidem may impair driving skills with a resultant increased risk of road traffic accidents. This adverse effect is not unique to zolpidem, but also occurs with other hypnotic drugs.

Motor vehicle drivers should exercise caution. In 2013, the FDA recommended reducing the dose for women and advised prescribers to consider lower doses for men due to impaired function the day after taking the drug.

Prescribing Zolpidem to older people is not advisable, as they are more sensitive to the effects of hypnotics including Zolpidem and are at an increased risk of falls and adverse cognitive effects, such as delirium and neurocognitive disorder.

The FDA has not assigned Zolpidem to a pregnancy category. Animal studies have shown evidence of incomplete ossification and increased intrauterine fetal death at doses exceeding seven times the maximum recommended human dose or higher. However, these studies did not observe teratogenic effects at any dose level. There is no controlled data available on human pregnancy. In one case report, zolpidem was detected in cord blood at delivery. It is advisable to use Zolpidem during pregnancy only if the benefits outweigh the risks.